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NICOLE OSIER, PHd, RN | ASSISTANT PROFESSOR, DIRECTOR OF THE BIOBEHAVORAL CORE OF ST. DAVID’S CHPR

Sharon Brown

Email Nicole Osier

Phone: 512 232-4755
Fax: 512 475-8755

Office: NUR 3.442
The University of Texas at Austin, School of Nursing
1710 Red River Street
Austin, TX 78701

Dr. Osier is an Assistant Professor and new addition to the University of Texas at Austin faculty. She holds joint appointments in the School of Nursing (Division of Holistic Adult Health) and Dell Medical School (Department of Neurology). Dr. Osier also serves as the Director of the Biobehavioral Core of St. David’s Center for Health Promotion and Disease Prevention Research in Underserved Populations (CHPR). Dr. Osier’s training background includes dual bachelor’s degrees from Michigan State University (in Nutritional Science and Nursing), a PhD from the University of Pittsburgh (in Nursing with an emphasis on Molecular Genomics), and a post-doctoral fellowship at the National Institutes of Health (in Nursing with an emphasis on Protein Quantification). To-date, Dr. Osier’s program of research has centered on using both pre-clinical and clinical research to promote understanding the molecular and genomic underpinnings of health, disease, and injury recovery. Her current research focuses on understanding the pathology associated with traumatic brain injury (TBI). Her ultimate goal is to harness this information to predict individuals at highest risk for poor outcomes and ultimately to inform precision care initiatives.

In addition to her research, Dr. Osier is very passionate about teaching and mentoring the next generation of registered nurses and nurse scientists. She currently teaches the Genetics in Healthcare course in the School of Nursing. She also enjoys working with students outside of the classroom, both in the laboratory and on manuscripts, presentations, grants, and other professional development activities. Additionally. Dr. Osier is committed to promoting the nursing profession and health science research community through her service efforts. She currently serves as the Co-Chair for the International Society of Nurses in Genetics (ISONG)’s Educational Products Subcommittee and is a member of the Council for the Advancement of Nursing Science’s Awards Committee. She also reviews abstracts for numerous professional societies and manuscripts for a number of nursing, medical, and basic science journals.

Ongoing Funding

  • Principal Investigator, Rising STARs Award of the Science and Technology Acquisition and Retention (STARs) Program, University of Texas System Permanent University Fund Bond; $250,000; 09/01/2017-08/31/2020.
  • Principal Investigator, Exploring Interleukin (IL)-15, IL-23, and IL-33 Levels in Traumatic Brain Injury: Potential for Injury Diagnosis and Psychiatric Symptom Prognosis; Heilbrunn Family Center for Research Nursing; $25,000; 07/01/2017-06/30/2018.

Completed Funding

  • Principal Investigator, Mechanism of Melatonin-induced Neuroprotection in Traumatic Brain Injury [F31NR014957]; National Institute of Nursing Research; $85,352; 09/01/2014-08/31/2016.
  • Principal Investigator, Melatonin Dose Response in Mice Following Traumatic Brain Injury; Walter L. Copeland Fund of the Pittsburgh Foundation; $8,000; 08/01/2016-07/31/2016.
  • Principal Investigator, Mechanism of Melatonin-Induced Neuroprotection Following Traumatic Brain Injury; Neurotrauma Nursing Foundation & American Association of Neuroscience Nursing; $8,435; 08/01/2014-07/31/2016.
  • Principal Investigator, Effects of Melatonin on Functional Outcomes in a Mouse Model of Brain Injury; Sigma Theta Tau International Eta Chapter; $2,500; 08/01/2014-07/31/2016.
  • Principal Investigator, Effect of Genotype on Response to Melatonin Therapy in Traumatic Brain Injury; International Society for Nurses in Genetics; $2,500; 12/01/2014-11/30/2015.
  • Principal Investigator, Mechanism of Melatonin-Induced Neuroprotection After Traumatic Brain Injury; Walter L. Copeland Fund of the Pittsburgh Foundation; $10,000; 08/01/2014-07/31/2015.
  • Principal Investigator, A Pre-Clinical Study of the Effects of Melatonin Therapy on Symptoms following Acute Brain Injury; University of Pittsburgh School of Nursing Wilkes Fund; $5,083; 08/01/2014-07/31/2015.

Journal Articles

  • Osier, N. & Dixon, C.E. (2017). Mini review of controlled cortical impact:  A well-suited device for concussion research. Brain Sciences, 7(7), 88. Epub 2017 Jul 20.  doi: 10.3390/brainsci7070088.
  • Osier, N.D., Pham, L., Pugh, B., Puccio, A.M., Ren, D., Conley, Y.P., Alexander, S., & Dixon, C.E. (2017). Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2. Neuroscience Letters.Epub 2017 Apr 2. doi: 10.1016/j.neulet.2017.03.053.
  • Gill, J., Motamedi, V., Osier, N., Dell, K., Arcurio, L., Carr, W., Walker, P., Ahlers, S., LoPresti, M., & Yarnell, Y. (2017). Moderate blast exposure results in increased IL-6 and TNF-alpha in peripheral blood. Brain Behavior and Immunity. Epub 2017 Feb 21. doi: 10.1016/j.bbi.2017.02.015.
  • Osier, N.D., Bales, J.W., Pugh, B., Shin, S., Wyrobek, J. Puccio, A.M., Okonkwo, D.O., Ren, D., Alexander, S., Conley, Y., & Dixon, C.E. (2017). Variation in PPP3CC is associated with long-term recovery after severe brain injury. Journal of Neurotrauma, 34(1), 86-96. doi: 10.1089/neu.2015.4343.
  • Osier, N.D., Pham, L., Savarese, A., Sayles, K., Alexander, S. (2016). Animal models in the era of molecular genomics: opportunities for nurses in research and clinical practice. Applied Nursing Research,32, 247-256. doi: 10.1016/j.apnr.2016.07.016.
  • Osier, N. & Dixon, C.E. (2016). The controlled cortical impact model of experimental brain trauma: overview, research applications, and protocol. Methods in Molecular Biology,1462, 177-92. doi: 10.1007/978-1-4939-3816-2_11.
  • Osier, N.D., Khalil, H., Zelazny, J., Imes, C., Johansson, A.E.E., & Conley, Y. (2016). Symptom science: Repurposing existing omics data. Biological Research for Nursing. Epub 2016 Sep 9. doi: 10.1177/1099800416666716.
  • Osier, N.D. & Dixon, C.E. (2016). The controlled cortical impact model: Applications, considerations for researchers, & future directions. Frontiers in Neurology: Neurotrauma, 7, 134. doi: 10.3389/fneur.2016.00134.
  • Osier ND, Dixon CE. (2016). Catecholaminergic based therapies for functional recovery after TBI. Brain Research, 1640(A), 15-35. doi: 10.1016/j.brainres.2015.12.026.
  • Goode, R.W., Ye, L., Sereika, S.M.  Zheng, Y., Mattos, M., Acharya, S.D., Ewing, L.J., Danford, C. Hu, L., Imes, C.C., Chasens, E., Osier, N., Mancino, J., Burke, L.E. (2016). Socio-demographic, anthropometric, & psychosocial predictors of attrition across behavioral weight loss trials. Eating Behaviors, 20, 27-33. doi: 10.1016/j.eatbeh.2015.11.009.
  • Osier, N., Carlson, S., DeSana, A., & Dixon, C. (2015). Chronic histopathological and behavioral outcomes of experimental traumatic brain injury in adult male animals. Journal of Neurotrauma, 32(23):1861-1882. doi: 10.1089/neu.2014.3680.
  • Bondi, C.O. Semple, B.D., Noble-Haeusslein L.J., Osier, N.D., Carlson, S.W., Dixon, C.E., Giza, C., & Kline, A.E. (2015). Found in translation understanding the biology and behavior of traumatic brain injury. Neuroscience & Biobehavioral Reviews,58,123-146.  doi: 10.1016/j.neubiorev.2014.12.004.
  • Stommel, M. & Osier, N. (2013). Temporal changes in bias of body mass index scores based on self-reported height and weight. International Journal of Obesity, 37(3):461-7. doi: 10.1038/ijo.2012.67.

Book Chapters

  • Osier, N. D., Korpon, J. R., & Dixon, C. E. (2015). Controlled cortical impact model.  In: F. Kobeissy (Ed.), Brain Injury Principles: Molecular Neuropsychological, and Eehabilitation Aspects in Brain Injury Models. Florence, Kentucky: Taylor & Francis Group. PMID: 26269887.
  • Yan, H.Q., Osier, N.D., Korpon, J., Bales, J.W., Kline, A.E., Wagner, A.K. & Dixon, C.E. (2015). Persistent cognitive deficits: implications of altered dopamine in acute traumatic brain injury. In: F. Kobeissy (Ed.), Brain Injury Principles: Molecular Neuropsychological, and Eehabilitation Aspects in Brain Injury Models. Florence, Kentucky: Taylor & Francis Group. PMID: 26269913.       

Selected Presentations

  • Osier, N.D. (2017). Applications of molecular genomic research techniques in my work and advice for nurses interested in genomics. National Institute for Nursing Research’s Summer Genetics Institute, Bethesda, MD, USA. [Podium]
  • Osier, N. (2017). Melatonergic system changes after experimental brain injury. Bloomberg University Emerging Nurse Scholars Forum, Toronto, Ontario, Canada. [Podium]
  • Osier, N.D., Gill, J., Edwards, K., Dell, K.C., Carr, W., Walker, P., Ahlers, S., LoPresti, M., & Yarnell, A. (2017). Amyloid-beta 40, Amyloid-beta 42, and tau as peripheral biomarkers for moderate blast exposure. National Capital Area TBI Conference, Bethesda, MD, USA.  [Podium]
  • Osier, N., Pham, L, Savarese, A., Pugh, B.J., Puccio, A., Ren, D., Conley, Y., Alexander, S., Dixon, C.E. (2016). Melatonin receptors are associated with TBI pathology in rodents and genetic variation in humans may be a determinant of health in humans. Council for the Advancement of Nursing Science, Washington, D.C., USA. [Poster]
  • Osier, N., Alexander, S., & Dixon, C. E. (2016). Applying pre-clinical methodologies to better understand the genetic and physiologic mechanisms underlying brain injury. Sigma Theta Tau International 27th International Nursing Research Congress, Cape Town, South Africa, Africa. [Poster]
  • Osier, N., Pugh, B., Puccio, A., Ren, D., Conley, Y., Alexander, S., and Dixon, C.E. (2016). Downregulation of MT1 and MT2 occurs after severe TBI in rats. National Neurotrauma Society, Lexington, KY, USA. [Poster]
  • Osier, N., Pugh, B., Puccio, A., Conley, Y., Alexander, S., Dixon, C.E. (2016). Downregulation of melatonin receptors MT1 and MT2 occurs after TBI in rats. Safar Symposium, Pittsburgh, PA, USA. [Poster]
  • Osier, N., Savarese, A., Pugh, B.J., Pham, L., Alexander, S. (2016). Utilizing pre-clinical research methodologies to explore the melatonergic system & address important gaps in the traumatic brain injury knowledge base. Pennsylvania Higher Education Nursing Schools Association Conference, State College, PA, USA. [Poster]
  • Osier, N., Pugh, B., Pham, L., Savarese, A., Alexander, A. (2016). Endogenous changes in melatonin receptor levels after traumatic brain injury in rats. Fink Scholars Day, Pittsburgh, PA, USA. [Poster]
  • Osier, N., Alexander, S., Conley, Y., Dixon, C.E. (2015). Association between calcineurin genotype & outcomes after severe TBI. International Society for Nurses in Genomics, Pittsburgh, PA, USA. [Podium]
  • Osier, N., Alexander, S., Conley, Y., Dixon, C.E. (2015). Association between calcineurin genotype & clinical outcomes after severe TBI. Society for Neuroscience, Chicago, IL, USA. [Poster]
  • Osier, N., Yan, H.Q. Ma, Xiecheng Ma, Mondello, S., Empey, P., Poloyac, S., Feldman, K., Wang, K., Hayes, R., Kochanek, P.M., Dixon, C.E. (2015). Evaluation of kollidon VA-64 in the controlled cortical impact model of traumatic brain injury: An OBTT Consortium Study. National Neurotrauma Society, Santa Fe, NM, USA. [Poster]
  • Baumgartel, K., Koleck, T., Osier, N., Conley, Y. (2015). Molecular Genomic Fellowship Program for Nurse Scientists. Doctoral Directions Learning to Lead in Biomedicine, Pittsburgh, PA, USA. [Poster]
  • Osier, N., Savarese, A., Dixon, C. Alexander, S. (2014). An opportunity for nurses to promote bench-to-bedside translation: Use of animal models for studying genetics and human health. International Society for Nurses in Genomics 2014 Congress, Scottsdale, AZ, USA. [Poster]
  • Osier, N. & Dixon, C.E. (2014). Effect of melatonin on novel object recognition after traumatic brain injury: A pilot study.  Society for Critical Care Medicine 43rd Critical Care Congress, San Francisco, CA, USA. [Poster]

Awards

  • 2017:  Rising Star of Research & Scholarship, Sigma Theta Tau International. [Award & Travel Grant]
  • 2016:  Top poster in Neurological Surgery, Safar Symposium. [Award]
  • 2016:  Travel Grant, National Neurotrauma Society. [Travel Grant]
  • 2015:  Best poster in Leadership/Training, University of Pittsburgh Doctoral Directions Conference. [Award]